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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
AAK1
All Species:
14.55
Human Site:
S731
Identified Species:
45.71
UniProt:
Q2M2I8
Number Species:
7
Phosphosite Substitution
Charge Score:
-0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q2M2I8
NP_055726.3
863
93578
S731
H
P
E
K
L
G
G
S
A
E
S
L
I
P
G
Chimpanzee
Pan troglodytes
XP_001138187
865
93810
S733
H
P
E
K
L
G
G
S
A
E
S
L
I
P
G
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_531855
473
51892
Q348
E
A
A
A
K
K
S
Q
P
K
A
R
L
T
D
Cat
Felis silvestris
Mouse
Mus musculus
Q3UHJ0
959
103328
S729
L
P
E
K
L
G
G
S
A
E
S
L
I
P
G
Rat
Rattus norvegicus
P0C1X8
962
103742
S732
L
P
E
K
L
G
G
S
A
E
S
L
I
P
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_417663
953
102927
I725
G
S
S
T
E
N
L
I
P
G
F
Q
P
A
S
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_625109
598
65629
S473
H
C
S
T
I
R
R
S
P
A
S
V
Q
D
T
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P40494
810
91014
K672
N
V
N
I
N
Q
E
K
K
E
S
I
Q
R
R
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
N.A.
53.7
N.A.
80.7
79.9
N.A.
N.A.
71.4
N.A.
N.A.
N.A.
N.A.
36.7
N.A.
N.A.
Protein Similarity:
100
99.6
N.A.
54.4
N.A.
83.1
82.7
N.A.
N.A.
77.9
N.A.
N.A.
N.A.
N.A.
50
N.A.
N.A.
P-Site Identity:
100
100
N.A.
0
N.A.
93.3
93.3
N.A.
N.A.
0
N.A.
N.A.
N.A.
N.A.
20
N.A.
N.A.
P-Site Similarity:
100
100
N.A.
20
N.A.
93.3
93.3
N.A.
N.A.
0
N.A.
N.A.
N.A.
N.A.
33.3
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
22
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
38.2
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
13
13
13
0
0
0
0
50
13
13
0
0
13
0
% A
% Cys:
0
13
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
13
13
% D
% Glu:
13
0
50
0
13
0
13
0
0
63
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
13
0
0
0
0
% F
% Gly:
13
0
0
0
0
50
50
0
0
13
0
0
0
0
50
% G
% His:
38
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
13
13
0
0
13
0
0
0
13
50
0
0
% I
% Lys:
0
0
0
50
13
13
0
13
13
13
0
0
0
0
0
% K
% Leu:
25
0
0
0
50
0
13
0
0
0
0
50
13
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
13
0
13
0
13
13
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
50
0
0
0
0
0
0
38
0
0
0
13
50
0
% P
% Gln:
0
0
0
0
0
13
0
13
0
0
0
13
25
0
0
% Q
% Arg:
0
0
0
0
0
13
13
0
0
0
0
13
0
13
13
% R
% Ser:
0
13
25
0
0
0
13
63
0
0
75
0
0
0
13
% S
% Thr:
0
0
0
25
0
0
0
0
0
0
0
0
0
13
13
% T
% Val:
0
13
0
0
0
0
0
0
0
0
0
13
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _